| Neural Tube Defects |
24.13 (22.08-26.33) |
1.50 (1.39-1.62) |
3.50 (3.33-3.68) |
4.44 (4.25-4.64) |
0.57 (0.50-0.64) |
Spina Bifida without anencephaly |
15.37 (13.48-17.45) |
0.62 (0.55-0.69) |
2.58 (2.44-2.73) |
2.69 (2.55-2.85) |
0.50 (0.44-0.57) |
Anencephaly |
86.03 (74.43-98.91) |
0.69 (0.61-0.77) |
0.41 (0.35-0.47) |
Suppressed |
Suppressed |
Encephalocele |
21.63 (17.07-27.03) |
0.20 (0.16-0.25) |
0.55 (0.48-0.62) |
0.69 (0.62-0.77) |
0.06 (0.04-0.09) |
| Selected genital anomalies |
0.65 (0.58-0.74) |
0.06 (0.04-0.09) |
57.31 (56.62-58.00) |
55.01 (54.33-55.69) |
2.41 (2.27-2.56) |
Cryptorchidism |
0.43 (0.35-0.52) |
Suppressed |
Suppressed |
56.98 (56.02-57.95) |
1.88 (1.71-2.07) |
Epispadias |
0 |
Suppressed |
Suppressed |
0.72 (0.64-0.80) |
0.15 (0.12-0.19) |
Hypospadias |
0.71 (0.59-0.85) |
Suppressed |
Suppressed |
48.11 (47.23-49.00) |
2.30 (2.11-2.50) |
Indeterminate sex |
10.26 (7.87-13.16) |
0.05 (0.03-0.07) |
1.14 (1.05-1.25) |
1.08 (0.98-1.18) |
0.12 (0.09-0.15) |
| Selected congenital heart defects |
10.88 (10.29-11.50) |
1.26 (1.16-1.37) |
20.19 (19.78-20.61) |
20.39 (19.97-20.80) |
1.21 (1.12-1.32) |
Transposition of great vessels |
11.39 (10.23-12.65) |
0.24 (0.20-0.29) |
5.35 (5.14-5.57) |
5.54 (5.32-5.76) |
0.11 (0.08-0.14) |
Endocardial cushion defects/AVSD |
10.06 (8.88-11.36) |
0.22 (0.18-0.26) |
4.60 (4.41-4.80) |
4.75 (4.55-4.95) |
0.07 (0.05-0.10) |
Tetralogy of Fallot |
8.37 (7.28-9.57) |
0.34 (0.29-0.40) |
4.36 (4.17-4.56) |
4.58 (4.39-4.78) |
0.12 (0.09-0.15) |
Hypoplastic left heart syndrome |
31.36 (28.53-34.40) |
0.43 (0.37-0.49) |
2.43 (2.29-2.58) |
2.82 (2.66-2.97) |
0.04 (0.03-0.07) |
Coarctation of aorta |
6.09 (5.29-6.97) |
0.06 (0.04-0.09) |
5.94 (5.72-6.17) |
5.13 (4.93-5.34) |
0.87 (0.79-0.96) |
Common Truncus |
18.58 (13.65-24.70) |
0.07 (0.05-0.10) |
0.45 (0.39-0.52) |
0.51 (0.45-0.58) |
0.02 (0.01-0.03) |
| Limb deficiency defects |
4.95 (4.07-5.97) |
0.24 (0.19-0.28) |
3.45 (3.28-3.62) |
3.56 (3.39-3.73) |
0.13 (0.10-0.17) |
| Oro-facial clefts |
3.64 (3.26-4.05) |
0.51 (0.45-0.58) |
15.84 (15.48-16.21) |
16.11 (15.75-16.48) |
0.25 (0.20-0.30) |
Cleft palate only |
3.52 (2.94-4.18) |
0.07 (0.05-0.10) |
6.31 (6.08-6.54) |
6.18 (5.95-6.41) |
0.20 (0.16-0.25) |
Cleft lip only |
1.65 (1.08-2.42) |
0.11 (0.08-0.15) |
2.72 (2.57-2.87) |
2.80 (2.65-2.96) |
0.03 (0.01-0.05) |
Cleft lip with cleft palate |
4.37 (3.75-5.06) |
0.33 (0.28-0.39) |
6.82 (6.58-7.06) |
7.13 (6.89-7.38) |
0.02 (0.01-0.03) |
| Diaphragmatic hernia |
22.90 (20.68-25.29) |
0.31 (0.26-0.36) |
2.88 (2.72-3.04) |
3.09 (2.93-3.25) |
0.10 (0.07-0.13) |
| Selected abdominal wall defects |
7.13 (6.22-8.12) |
0.55 (0.49-0.63) |
5.01 (4.80-5.22) |
5.49 (5.27-5.70) |
0.08 (0.05-0.11) |
Omphalocele/Exomphalos |
11.76 (9.98-13.75) |
0.36 (0.30-0.42) |
1.80 (1.68-1.93) |
2.09 (1.96-2.23) |
0.07 (0.05-0.10) |
Gastroschisis |
3.91 (3.06-4.92) |
0.21 (0.17-0.26) |
3.24 (3.08-3.41) |
3.44 (3.28-3.62) |
0.01 (0.00-0.03) |
| Selected gastrointestinal defects |
5.39 (4.90-5.91) |
0.15 (0.12-0.19) |
14.26 (13.92-14.61) |
12.20 (11.88-12.52) |
2.55 (2.41-2.70) |
Oesophageal atresia/stenosis, tracheoesophageal fistula |
9.77 (8.35-11.36) |
0.04 (0.02-0.06) |
2.84 (2.69-3.00) |
2.59 (2.45-2.75) |
0.45 (0.39-0.52) |
Small intestine absence/atresia/stenosis |
5.48 (4.57-6.52) |
0.06 (0.04-0.09) |
4.07 (3.89-4.26) |
3.78 (3.61-3.96) |
0.38 (0.33-0.44) |
Ano-rectal absence/atresia/stenosis |
6.84 (5.76-8.06) |
0.05 (0.03-0.08) |
3.54 (3.37-3.71) |
3.42 (3.25-3.59) |
0.20 (0.16-0.24) |
Hirschsprung disease |
1.24 (0.80-1.83) |
0 |
3.52 (3.35-3.69) |
2.11 (1.98-2.24) |
1.41 (1.30-1.52) |
Atresia of bile ducts |
6.75 (4.82-9.19) |
0 |
1.05 (0.96-1.14) |
0.88 (0.79-0.97) |
0.17 (0.13-0.21) |
| Selected chromosomal defects |
15.58 (14.75-16.44) |
4.55 (4.36-4.75) |
15.14 (14.79-15.50) |
16.96 (16.59-17.34) |
2.75 (2.60-2.90) |
Down syndrome |
8.81 (8.14-9.53) |
2.39 (2.25-2.53) |
12.68 (12.35-13.01) |
12.86 (12.53-13.19) |
2.20 (2.07-2.34) |
Trisomy 13 (Patau) |
65.98 (57.60-75.23) |
0.49 (0.43-0.56) |
0.62 (0.55-0.69) |
1.02 (0.93-1.12) |
0.09 (0.06-0.12) |
Trisomy 18 (Edwards) |
66.95 (61.06-73.26) |
1.39 (1.29-1.50) |
1.29 (1.19-1.40) |
2.47 (2.33-2.62) |
0.22 (0.18-0.27) |
Turner syndrome |
5.70 (3.57-8.63) |
0.62 (0.52-0.73) |
1.31 (1.17-1.47) |
1.42 (1.27-1.58) |
0.51 (0.43-0.62) |
| Other central nervous system defects |
17.92 (16.34-19.61) |
1.06 (0.97-1.16) |
4.76 (4.56-4.96) |
5.42 (5.21-5.64) |
0.42 (0.37-0.49) |
Hydrocephaly |
14.35 (12.86-15.96) |
0.67 (0.60-0.75) |
4.25 (4.07-4.44) |
4.55 (4.36-4.75) |
0.39 (0.33-0.45) |
Arhinencephaly/Holoprosencephaly |
45.42 (38.19-53.64) |
0.39 (0.34-0.46) |
0.56 (0.49-0.63) |
0.92 (0.83-1.01) |
0.04 (0.02-0.06) |
| Selected urinary tract defects |
8.22 (7.59-8.89) |
1.04 (0.95-1.14) |
12.06 (11.74-12.38) |
12.13 (11.81-12.45) |
1.03 (0.94-1.13) |
Renal agenesis |
8.02 (7.03-9.11) |
0.55 (0.49-0.63) |
4.56 (4.37-4.76) |
4.72 (4.53-4.93) |
0.39 (0.34-0.46) |
Cystic kidney |
9.62 (8.67-10.65) |
0.44 (0.38-0.50) |
6.28 (6.05-6.51) |
6.25 (6.02-6.48) |
0.48 (0.42-0.55) |
Bladder and cloacal exstrophy |
7.27 (3.75-12.70) |
0.03 (0.02-0.05) |
0.29 (0.25-0.35) |
0.32 (0.27-0.37) |
0.01 (0.00-0.03) |
Lower urinary tract obstruction |
5.27 (3.95-6.89) |
0.05 (0.04-0.08) |
1.50 (1.39-1.62) |
1.42 (1.31-1.53) |
0.15 (0.11-0.19) |
| Selected sense organ defects |
5.40 (4.58-6.32) |
0.05 (0.04-0.08) |
4.37 (4.18-4.56) |
3.80 (3.63-3.99) |
0.62 (0.55-0.70) |
Anophthalmos/Microphthalmos |
14.84 (11.69-18.58) |
0.04 (0.03-0.07) |
0.81 (0.73-0.89) |
0.81 (0.73-0.90) |
0.04 (0.02-0.06) |
Anotia/Microtia |
2.34 (1.41-3.65) |
Suppressed |
Suppressed |
1.31 (1.21-1.42) |
0.01 (0.00-0.03) |
Choanal Atresia |
4.30 (3.34-5.45) |
0.01 (0.00-0.03) |
2.33 (2.19-2.47) |
1.77 (1.65-1.89) |
0.57 (0.51-0.65) |